Regenerative Potential of Ependymal Cells for Spinal Cord Injuries Over Time
نویسندگان
چکیده
منابع مشابه
Regenerative Potential of Ependymal Cells for Spinal Cord Injuries Over Time
Stem cells have a high therapeutic potential for the treatment of spinal cord injury (SCI). We have shown previously that endogenous stem cell potential is confined to ependymal cells in the adult spinal cord which could be targeted for non-invasive SCI therapy. However, ependymal cells are an understudied cell population. Taking advantage of transgenic lines, we characterize the appearance and...
متن کاملStem cells for spinal cord injuries bearing translational potential
Spinal cord injury (SCI) is a highly debilitating neurological disease, which still lacks effective treatment strategies, causing significant financial burden and distress to the affected families. Nevertheless, nanotechnology and regenerative medicine strategies holding promise for the development of novel therapies that would reach from bench to bedside to serve the SCI patients. There has al...
متن کاملRecent advances in regenerative medicine approaches for spinal cord injuries
Traumatic injury to the spinal cord leads to a loss of motor and sensory function below the level of injury. The lack of growthassociated proteins, local expression of inhibitory factors, and scar and cyst formation create an inhibitory environment in the spinal cord, which limits the regenerative capacity of endogenous or transplanted cells. Cell and drug delivery strategies, either alone or i...
متن کاملSpinal Cord Injury Reveals Multilineage Differentiation of Ependymal Cells
Spinal cord injury often results in permanent functional impairment. Neural stem cells present in the adult spinal cord can be expanded in vitro and improve recovery when transplanted to the injured spinal cord, demonstrating the presence of cells that can promote regeneration but that normally fail to do so efficiently. Using genetic fate mapping, we show that close to all in vitro neural stem...
متن کاملEpendymal cyst of the thoracic spinal cord.
A unique case of an ependymal cyst on the anterior aspect of the thoracic spinal cord in a woman aged 68 years is described. Clinical signs were precipitated by trauma. Recovery of function, while incomplete, was remarkably good after extirpation of the cyst.
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: EBioMedicine
سال: 2016
ISSN: 2352-3964
DOI: 10.1016/j.ebiom.2016.10.035